There are 37 cars on the preliminary entry list for the 2022 NASCAR Cup Series Pennzoil 400 at Las Vegas Motor Speedway.
Greg Biffle, in the No. 44 NY Racing entry, is the only open car in the field. Biffle will make the field as up to 40 cars can start a NASCAR Cup Series event.
| # | Driver | Manufacturer | Sponsor | Team | |
|---|---|---|---|---|---|
| 1 | 1 | Ross Chastain | Chevrolet | ACM Awards | Trackhouse Racing |
| 2 | 2 | Austin Cindric | Ford | Discount Tire | Team Penske |
| 3 | 3 | Austin Dillon | Chevrolet | BREZTRI | Richard Childress Racing |
| 4 | 4 | Kevin Harvick | Ford | Rheem / Smurfit Kappa | Stewart-Haas Racing |
| 5 | 5 | Kyle Larson | Chevrolet | HendrickCars.com | Hendrick Motorsports |
| 6 | 6 | Brad Keselowski | Ford | Fastenal | RFK Racing |
| 7 | 7 | Corey LaJoie | Chevrolet | Schluter Systems | Spire Motorsports |
| 8 | 8 | Tyler Reddick | Chevrolet | BetMGM | Richard Childress Racing |
| 9 | 9 | Chase Elliott | Chevrolet | NAPA Auto Parts | Hendrick Motorsports |
| 10 | 10 | Aric Almirola | Ford | Mobil1 | Stewart-Haas Racing |
| 11 | 11 | Denny Hamlin | Toyota | FedEx Freight | Joe Gibbs Racing |
| 12 | 12 | Ryan Blaney | Ford | Menards/Pennzoil | Team Penske |
| 13 | 14 | Chase Briscoe | Ford | Mahindra Tractors | Stewart-Haas Racing |
| 14 | 15 | Garrett Smithley | Ford | Trophy Tractor | Rick Ware Racing |
| 15 | 16 | Daniel Hemric | Chevrolet | South Point | Kaulig Racing |
| 16 | 17 | Chris Buescher | Ford | Wyndham Rewards | RFK Racing |
| 17 | 18 | Kyle Busch | Toyota | Ethel M Chocolates | Joe Gibbs Racing |
| 18 | 19 | Martin Truex Jr. | Toyota | Bass Pro Shops | Joe Gibbs Racing |
| 19 | 20 | Christopher Bell | Toyota | DEWALT | Joe Gibbs Racing |
| 20 | 21 | Harrison Burton | Ford | Motorcraft / Quick Lane | Wood Brothers Racing |
| 21 | 22 | Joey Logano | Ford | Pennzoil | Team Penske |
| 22 | 23 | Bubba Wallace | Toyota | Dr. Pepper Cream Soda | 23XI Racing |
| 23 | 24 | William Byron | Chevrolet | Axalta | Hendrick Motorsports |
| 24 | 31 | Justin Haley | Chevrolet | LeafFilter Gutter Protection | Kaulig Racing |
| 25 | 34 | Michael McDowell | Ford | Stage Front Ticketing | Front Row Motorsports |
| 26 | 38 | Todd Gilliland | Ford | Frontline Enterprises | Front Row Motorsports |
| 27 | 41 | Cole Custer | Ford | HaasTooling.com | Stewart-Haas Racing |
| 28 | 42 | Ty Dillon | Chevrolet | Goettl Air Conditioning | Petty GMS Motorsports |
| 29 | 43 | Erik Jones | Chevrolet | FOCUSfactor | Petty GMS Motorsports |
| 30 | 44 | Greg Biffle | Chevrolet | Florida A&M University | NY Racing Team |
| 31 | 45 | Kurt Busch | Toyota | Monster Energy | 23XI Racing |
| 32 | 47 | Ricky Stenhouse Jr. | Chevrolet | SunnyD | JTG Daugherty Racing |
| 33 | 48 | Alex Bowman | Chevrolet | Ally Financial | Hendrick Motorsports |
| 34 | 51 | Cody Ware | Ford | Nurtec ODT | Rick Ware Racing |
| 35 | 77 | Josh Bilicki | Chevrolet | Zeigler Auto Group | Spire Motorsports |
| 36 | 78 | BJ McLeod | Ford | Filter Time | Live Fast Motorsports |
| 37 | 99 | Daniel Suarez | Chevrolet | CommScope | Trackhouse Racing |
